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Can trintellix be cut in half

Trintellix unwanted side effects | Weight acquire | Withdrawal | How lengthy do unwanted side effects final? | Warnings | Interactions | Learn how to keep away from unwanted side effects

Trintellix (energetic ingredient: vortioxetine) is a brand-name prescription drug that treats main depressive dysfunction (MDD). Vortioxetine, the energetic ingredient in Trintellix, balances serotonin within the mind, which can assist enhance temper, reminiscence, and cognitive perform in these with melancholy. Trintellix is an efficient remedy, but it surely might not be the best remedy for everybody due to doable unwanted side effects.

See more: Can trintellix be cut in half

RELATED: Study extra about Trintellix | Get Trintellix reductions

Frequent unwanted side effects of Trintellix

The most typical unwanted side effects of Trintellix are:

  • Nausea
  • Diarrhea
  • Dry mouth
  • Dizziness
  • Constipation
  • Vomiting
  • Flatulence
  • Irregular goals
  • Itching
  • Sexual dysfunction

Drowsiness just isn’t recognized to be a standard facet impact of vortioxetine. As a substitute, vortioxetine might enhance sleep cycles and assist cut back daytime drowsiness.

Trintellix weight adjustments

Antidepressants, notably selective serotonin reuptake inhibitors (SSRIs), are recognized for being related to weight acquire, however whether or not they really trigger weight acquire is way from sure. Trintellix, then again, seems to have minimal results on physique weight. In scientific research that adopted sufferers over six months, Trintellix, then known as Brintellix, had no important results on physique weight. A later year-long research, nonetheless, confirmed sufferers gained a mean of 1 (1) pound whereas on Trintellix. About 18% of research individuals taking Trintellix gained or misplaced 7% of their authentic weight initially of the research. Trintellix, then, has much less of an impact on weight than different antidepressants, however weight adjustments are doable and can fluctuate by individual.

Trintellix withdrawal

Like all medicines that have an effect on serotonin within the mind, Trintellix shouldn’t be discontinued abruptly. Though the drug just isn’t addictive, the dose must be regularly decreased over a number of weeks earlier than stopping to stop discontinuation signs. The most typical Trintellix discontinuation signs are:

  • Nausea
  • Sweating
  • Agitation
  • Irritability
  • Dizziness
  • Nervousness
  • Confusion
  • Insomnia

Discontinuation syndrome signs might take a number of hours to 3 days to seem and will persist for one or two weeks. Often, these signs resolve with out therapy in a single to 2 weeks.

Critical unwanted side effects of Trintellix

Trintellix could cause severe unwanted side effects together with:

  • Suicidal ideas and behaviors
  • Serotonin syndrome
  • Bleeding issues
  • Mania or hypomania in sufferers with bipolar dysfunction
  • Angle-closure glaucoma
  • Low sodium ranges
  • Extreme allergic reactions, together with anaphylaxis or angioedema


Trintellix comes with an FDA black field warning that kids, adolescents, and younger adults are at an elevated threat of suicidal ideas and behaviors. When taking Trintellix, youthful sufferers must be intently monitored for indicators of suicidality similar to:

  • Ideas or feedback about suicide
  • Makes an attempt to commit suicide
  • Uncommon temper adjustments
  • Anger, irritability, or aggression
  • Agitation or restlessness
  • New or worsening melancholy
  • New or worsening anxiousness
  • Panic assaults
  • Uncommon behaviors
  • Threat-taking behaviors or harmful impulses

Serotonin syndrome

Antidepressants like vortioxetine might trigger serotonin syndrome, a probably hazardous situation brought on by an excessive amount of serotonin within the mind. Discontinue Trintellix instantly and search medical care at indicators of serotonin syndrome, similar to:

  • Agitation
  • Hallucinations
  • Lack of coordination
  • Muscle twitching
  • Inflexible muscle tissues
  • Fast heartbeat
  • Excessive or low blood strain
  • Sweating
  • Fever
  • Nausea or vomiting
  • Confusion
  • Temper adjustments
  • Diarrhea
  • Seizures

Low blood sodium

Serotonergic medicine like vortioxetine might trigger SIADH, an issue with the hormone that controls the physique’s elimination of water and electrolytes from the physique. SIADH in flip may trigger the focus of salt (sodium) within the blood to fall, a situation known as hyponatremia. Low blood sodium could be a severe and probably hazardous medical situation, so search medical care at indicators of hyponatremia together with:

  • Confusion
  • Reminiscence loss
  • Headache
  • Nausea
  • Problem concentrating
  • Unsteadiness
  • Hallucinations
  • Fainting
  • Seizures
  • Coma

Angle-closure glaucoma

Angle-closure glaucoma can occur all of a sudden and trigger imaginative and prescient loss or blindness in only a few hours or days. It occurs when the drainage system for the attention situated between the iris and the cornea is blocked, inflicting fluid to rapidly accumulate inside the eye. Look ahead to signs similar to:

  • Eye ache
  • Imaginative and prescient adjustments
  • Pink or swollen eyes
  • Headache

Folks with “slim angles” between the iris and the cornea are most in danger for creating angle-closure glaucoma. A analysis of slim angles could be made throughout a routine eye examination. Slim angles are treatable by surgical procedure.

How lengthy do Trintellix unwanted side effects final?

The most typical Trintellix unwanted side effects are short-term and can often fade inside a number of days after the remedy is discontinued. Extreme unwanted side effects, nonetheless, might take longer to resolve. Gentle circumstances of serotonin syndrome usually resolve inside two to 3 days of discontinuing the remedy, however extreme circumstances require speedy medical consideration. In symptomatic circumstances of low blood sodium, Trintellix must be discontinued and a healthcare supplier must be contacted. Extreme circumstances of low blood sodium ranges might require hospitalization.

Trintellix contraindications & warnings

Trintellix might not be the best remedy for everybody. For a wide range of causes, some folks might not be capable to take the remedy whereas others might have to be cautious earlier than beginning it.

Allergy symptoms

Anybody with extreme allergy symptoms to Trintellix shouldn’t take the remedy.

MAO inhibitors

Folks taking monoamine oxidase inhibitors (MAOIs), a category of medicine that features some kinds of antidepressants, antibiotics, or medicine that deal with Parkinson’s illness, is not going to be prescribed Trintellix till they’ve stopped taking MAO inhibitors for at the least 14 days.

Poor metabolizers

Some folks don’t break down vortioxetine very properly. The drug then lingers for an extended time within the physique at greater concentrations, rising the chance for unwanted side effects. Luckily, folks could be genetically examined. Poor metabolizers will likely be restricted to a most each day dose of 10 milligrams (mg).


Trintellix is FDA accepted to be used in adults 18 and older. Trintellix has not been decided as both protected or efficient in kids.


In scientific trials, Trintellix has been proven to be efficient and protected in sufferers older than 65. No dose adjustment is required.

Being pregnant and breastfeeding

There may be not sufficient analysis or info figuring out that Trintellix is protected to take throughout being pregnant. People who find themselves pregnant or contemplating being pregnant ought to search medical recommendation from a healthcare skilled earlier than beginning or discontinuing Trintellix.

Likewise, there may be not sufficient analysis or info on whether or not Trintellix passes into breast milk or impacts a nursing child. The Medicine and Lactation Database (Nationwide Library of Medication) advises moms who’re taking Trintellix to modify to different medicines earlier than breastfeeding an toddler. The opposite different is to discover a totally different strategy to feed the toddler.

Trintellix interactions

Trintellix has a number of drug interactions that may trigger a wide range of adversarial results.

Trintellix and MAO inhibitors

Trintellix shouldn’t be taken with monoamine oxidase inhibitors (MAOIs). Combining Trintellix with an MAO inhibitor might trigger serotonin syndrome. These medicine embody:

  • Parnate (tranylcypromine)
  • Marplan (isocarboxazid)
  • Nardil (phenelzine)
  • Zyvox (linezolid)
  • Sivextro (tedizolid)
  • Emsam (selegiline)
  • Xadago (safinamide)
  • Methylene blue injections

Trintellix and serotonergic medicine

Medicine that elevate serotonin ranges are known as serotonergic medicine. A few of these medicines have a giant impact on serotonin, whereas others don’t. The chance for serotonin syndrome could be very low however will increase when two or extra serotonergic medicine are taken collectively. Because of this, combining different serotonergic medicine with Trintellix is to be prevented. These embody:

  • Antidepressants similar to
    • Tricyclic antidepressants
    • SSRIs (selective serotonin reuptake inhibitors), similar to citalopram, paroxetine, sertraline, or fluoxetine
    • SNRIs (selective serotonin and norepinephrine reuptake inhibitors), similar to duloxetine or venlafaxine
    • Wellbutrin (bupropion)
  • Nervousness medicines similar to buspirone
  • Stimulants
  • Medicine that deal with or forestall nausea
  • Cough medicines containing dextromethorphan
  • Migraine medicines together with triptans and ergot medicine
  • Opioids similar to tramadol or fentanyl
  • Antipsychotics
  • Anticonvulsants similar to carbamazepine or phenytoin
  • Parkinson’s medicines
  • Lithium
  • Natural dietary supplements similar to St. John’s wort, tryptophan, or Yohimbe

Trintellix and blood thinners (anticoagulants)

Trintellix raises the chance of bleeding issues, so remedy will have to be monitored if an individual can also be taking blood-thinners, similar to warfarin or Plavix (clopidogrel). Nonsteroidal anti-inflammatory medicine (NSAIDs), similar to aspirin and ibuprofen, additionally intrude with blood clotting, so they need to be used sparingly when taking Trintellix. Some anticancer medicine additionally increase the chance of bleeding episodes when taken with Trintellix. Lastly, steroids could cause gastrointestinal bleeding. The chance of bleeding issues will increase when these medicines are taken with Trintellix.

Many individuals are unaware that some common dietary and natural dietary supplements intrude with blood clotting, so these, too, must be used sparingly when taking Trintellix. They embody:

  • Garlic
  • Ginkgo
  • Krill oil
  • Noticed palmetto
  • Willow bark

Trintellix and diuretics

Trintellix raises the chance of low sodium ranges within the blood. Diuretics (water capsules) may contribute to the issue by rising the excretion of sodium. Remedy with diuretics might have to be monitored or modified. Sulfonylurea medicine, prescribed to manage blood sugar in sufferers with sort 2 diabetes, can even enhance the chance for low sodium in folks taking Trintellix.

Medicine that lower the effectiveness of Trintellix

Some medicine velocity up the physique’s metabolism of vortioxetine, decreasing its effectiveness. These embody:

  • The antibiotics rifampin, rifapentine, rifamycin, rifaximin, and rifabutin
  • Sure kinds of anticonvulsant medicine
  • Some kinds of antiviral medicine
  • Barbiturates similar to butalbital and butabarbital

When taking these medicine, the Trintellix dose might have to be elevated.

Medicine that enhance the unwanted side effects of Trintellix

Some medicine decelerate the physique’s metabolism of vortioxetine, rising the incidence and severity of doable unwanted side effects. These embody:

  • Some antidepressants like Wellbutrin (bupropion), Paxil (paroxetine), or Prozac (fluoxetine)
  • Sure medicine that deal with an irregular coronary heart fee similar to quinidine

A healthcare supplier might have to lower the Trintellix dose by as a lot as half when taken with these medicines.

Trintellix and alcohol

There isn’t any proof consuming alcohol will trigger extra impairment whereas taking vortioxetine. The producer, nonetheless, advises people to keep away from consuming alcohol whereas taking Trintellix.

Learn how to keep away from Trintellix unwanted side effects

Not everybody taking Trintellix will expertise unwanted side effects. For those who do, unwanted side effects will typically be minimal. There are, nonetheless, a number of methods to scale back the chance of unwanted side effects:

1. Take Trintellix as directed

Take the dose prescribed, often 5 to twenty mg as soon as each day. Don’t take further medication, minimize the dose, or skip a day or two. Trintellix could be taken with a meal or on an empty abdomen.

2. Don’t cease taking Trintellix all of a sudden

Keep away from stopping Trintellix suddenly. There could also be unwanted side effects. If the drugs doesn’t appear to be working or unwanted side effects are arduous to take, speak to the prescribing doctor, a pharmacist, or different healthcare skilled about altering the dose or switching to a brand new remedy. Whether it is agreed the remedy must be discontinued, the easiest way is to steadily taper the dose in response to your healthcare supplier’s directions.

3. Don’t miss doses

Like all antidepressants, folks get much less profit from the remedy in the event that they miss doses. If too many doses are missed in a row, signs of the situation being handled might return. It’s useful to maintain a medicine diary, use a medicine app, arrange a seven-day pillbox, or set an alarm for every day’s dose.

4. Inform the physician about all medical circumstances

Sharing a full medical historical past may help forestall unwanted side effects. Earlier than beginning Trintellix, inform your physician when you have had any of the next:

  • A historical past of seizures
  • Any issues with low sodium
  • Any issues with bleeding
  • Mania or bipolar dysfunction
  • Glaucoma

Additionally ensure you inform the physician about being pregnant, nursing, or any plans to turn into pregnant or nurse a child.

5. Inform the physician about all medicines being taken

Trintellix has a number of adversarial results because of drug interactions. Inform the prescribing physician about all the medicines and dietary supplements you’re taking, notably:

  • Medicines that deal with temper, anxiousness, psychosis, or different psychiatric issues
  • MAO inhibitors
  • Blood thinners
  • Diuretics
  • Migraine medicines
  • Ache medicines similar to opioids or NSAIDs
  • Anticonvulsants
  • Rifampicin
  • Quinidine
  • Throughout-the-counter medicines, dietary supplements, and natural cures you’re taking, particularly St. John’s wort and tryptophan

In case you are uncertain a few drug, a doctor, pharmacist, or different healthcare supplier may help you establish it. In case you are taking two or extra prescription medicines, maintain a listing of all these medicines readily available. Be able to seek the advice of that checklist when speaking to a healthcare skilled.


  • Antidepressant discontinuation syndrome, American Household Doctor
  • Trintellix, Epocrates
  • Trintellix Medicine Information, Takeda Prescription drugs
  • Vortioxetine, StatPearls
  • Vortioxetine (Trintellix), Nationwide Alliance on Psychological Sickness (NAMI)
  • Antidepressant utilisation and incidence of weight acquire throughout 10 years’ follow-up; inhabitants primarily based cohort research, BMJ
  • Antidepressants trigger minimal weight acquire, Harvard Well being
  • Melancholy, StatPearls
  • Drug-induced serotonin syndrome, U.S. Pharmacist
  • Main Depressive Dysfunction, StatPearls
  • “Slim angles” a tip-off to eyesight threat, Harvard Well being
  • Vortioxetine, Lactation and Drug Database
  • Vortioxetine compound abstract, Nationwide Library of Medication
  • Weight acquire and antidepressants, Journal of Scientific Psychiatry

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